Cardiovascular Vitality · CCV-3®

27% lower cardiovascular death over 3.6 years.

The dose studied in 21,442 adults in the COSMOS trial — delivered in a single daily ritual. NEJM-class evidence. One scoop. Once a day.

The heart keeps a longer record than memory.

Begin the heart ritual COSMOS · NEJM-class · Am J Clin Nutr 2022
Cacao flavanols supporting vascular endothelial function
Plate I · The MechanismCacao flavanols at the endothelial wall
21,442
Adults in COSMOS
3.6 yrs
Daily follow-up
1,200 mg
Cacao flavanols / day
NEJM-class
Evidence tier
Cellular geometry — the architecture of vascular renewal
The architecture of renewal — vascular, cellular, daily
The COSMOS outcomes

What the largest cacao trial ever run actually measured.

27 %

Lower cardiovascular death over 3.6 years

Pre-specified secondary endpoint in the COSMOS trial of 21,442 adults randomized to daily cocoa flavanols vs. placebo. Driven by the dose, not the food.

COSMOS · Am J Clin Nutr 2022 · PMID 35294962
2.2 x

More circulating vascular repair cells

Adults taking the cacao-flavanol dose mobilized 2.2× more endothelial progenitor cells than placebo — the body's own repair crew for damaged artery lining.

Heiss et al · JACC · 2010
21,442

Adults studied at this exact dose

The largest randomized trial ever run on this nutrient class. 3.6 years of daily intake. Brigham & Women's Hospital. Harvard Medical School. Funded by the NIH.

Brigham & Women's Hospital · Harvard Medical School
What it is
Epicatechin — the active flavanol molecule
Epicatechin · the active flavanol
What it does
Placebo vs HMD — vascular outcome divergence
Placebo vs CCV-3® · Δ vascular outcome
The mechanism

How cacao flavanols open the lining of every artery.

The endothelium is the single-cell layer lining every artery in your body. When it relaxes, blood flows. When it stiffens, pressure rises. Cacao flavanols speak directly to it.

  • Epicatechin enters circulation — standardized to 600 mg per scoop, the active monomer Schroeter isolated as the vascular agent of cocoa.
  • eNOS upregulates — endothelial nitric oxide synthase activity rises, releasing NO that relaxes the artery wall.
  • Repair cells mobilize — Heiss 2010 measured 2.2× more circulating endothelial progenitor cells — the lining's own maintenance crew.
  • Flow-mediated dilation improves — Schroeter 2006 measured a 14% gain in FMD, the gold-standard vascular function metric.
Heiss · JACC 2010 · Schroeter · PNAS 2006
Light returning from within — daily ritual, cumulative effect

Not energy you feel. Function you live with.

The daily ritual · 1,200 mg cacao flavanols · 90 days to feel it
HarmonyMD CCV-3 jar
Built for the daily ritual

The COSMOS dose, in one daily ritual.

Standardized to the 1,200 mg cacao-flavanol dose studied in COSMOS. No proprietary blends. No filler.

  • 1,200 mg cacao flavanols — the COSMOS dose, every scoop, every batch.
  • 600 mg standardized epicatechin — the vascular agent isolated by Schroeter et al.
  • One scoop, once a day — 8 oz oat milk or hot water. Morning ritual.
  • Standardized to the COSMOS dose — every batch standardized to the COSMOS dose before it ships.
Begin the heart ritual
The daily ritual

One cup. Once a day. The arc that matters is long.

The COSMOS benefit was cumulative over 3.6 years of daily use — not occasional. Cardiovascular health is built in the small consistent act, not the heroic one. Pour the cup. Drink it warm. Let the trial run in your own body.

Start your ritual
A hand placed gently on the chest — the daily ritual
One cup. Once a day. The arc that matters is long.

Real heart-health customers.

"The dose is what sold me. 1,200mg matches every study I read before buying."
Sarah J. · Real Buyer · March 2026
4.9 out of 5
Based on 1,247 customer reviews
What Customers Report

Consistently, across the community.

⚡
Steadier energy 94%
◎
Sharper focus 88%
♥
Warmer circulation 81%
☾
Better sleep 76%

Aggregated from 1,247 customer reviews — self-reported, not clinical claims.

E
Evelyn Niles
Real buyer
March 2026
No more afternoon crash
I was a little concerned at first — I've been disappointed by so many health products. Happy I took the chance on Harmony MD. Noticeable difference in my daily energy and clarity.
Real Buyer
J
Julie L. Young
Real buyer
February 2026
Morning stiffness is significantly better
This product has worked wonders on my circulatory health. I noticed improvement after 7 days — and I've already ordered a second 3-pack.
Real Buyer
D
Diana Sloan
Real buyer
January 2026
Focus at work has doubled
Easy to make, supports my cognitive function, and doesn't cause any stomach upset. I recommend taking this daily for the nitric oxide benefits.
Real Buyer
R
Robert D.
Real buyer
December 2025
The flavanol potency is clearly there
I've explored cacao extracts for years. Harmony completely solves the dosing problem. You can feel the difference in the first week.
Real Buyer
Read all 1,247 reviews →

Frequently asked questions.

01 What is Harmony MD Cacao Cellular Complex?
A cacao powder developed with physician input, delivering 1,200mg of flavanols per scoop — the studied dose from the COSMOS trial published in the American Journal of Clinical Nutrition.
02 How long until I notice results?
Most users notice changes within 7–14 days. The COSMOS trial measured outcomes across 3.6 years of daily use, so the cumulative effect builds with consistent use.
03 Is it allergen-free?
Yes. The formula is vegan, non-GMO, gluten-free, soy-free, and contains no artificial sweeteners, fillers, or preservatives. Five ingredients only.
04 What is CCV-3® and why does it matter?
CCV-3® is our internal quality standard ensuring each batch delivers exactly 1,200mg of cacao flavanols with 600mg standardized epicatechin — built around the same flavanol and epicatechin mechanism studied in COSMOS, at 2.4× the trial flavanol dose. Without standardization, you can't reproduce the mechanism reliably.
05 How is each batch standardized?
Every batch is standardized to the CCV-3® protocol — 1,200 mg of cacao flavanols and 600 mg of (−)-epicatechin per scoop. Verified to spec before it ships.
06 How do I manage my subscription?
Log in to your account portal to pause, skip, change frequency, or cancel at any time. No minimums. No penalties.
07 How long does one jar last?
Each jar contains 30 servings at the studied 10g daily scoop — one full month of the morning ritual at the COSMOS dose. Subscribers receive a fresh jar every 30 days so their supply never lapses.
08 Can I take Harmony with other medications?
Always consult your physician before adding any supplement to your regimen, particularly if you take blood thinners, statins, or blood pressure medication. The COSMOS trial included participants on various medications; your clinician knows your case.
09 Does Harmony have any caffeine?
Each serving contains approximately 12mg of naturally occurring caffeine — less than a quarter of a standard cup of coffee. This is naturally present in cacao and cannot be removed without destroying the flavanols.
10 How long does one bag last?
One bag contains approximately 30 servings when used as directed.
11 Is Harmony sweetened?
No. Harmony contains no added sugar and no artificial sweeteners.
12 Why have more than 200,000 people tried Harmony?
Many customers are looking for a simple daily ritual built around concentrated cocoa flavanols rather than highly processed chocolate products.
13 What happened to the cacao in modern chocolate?
Many chocolate products are formulated for taste first. During processing, the naturally occurring cocoa compounds researchers study can be significantly reduced.
14 Why are flavanols missing from most chocolate?
Flavanols are sensitive compounds. Traditional processing methods used to create sweeter, smoother chocolate often reduce their concentration.
15 If chocolate comes from cacao, why doesn’t chocolate provide the same benefits?
Chocolate and high flavanol cacao are not the same thing. The amount of flavanols can vary dramatically depending on how the cacao is processed.
CCV-3® Standard 1,200 mg Standardized Flavanols Standardized cacao flavanol complex Standardized to spec 1,200 mg cacao flavanols / scoop Vegan · Non-GMO Subscribe & Save 20% CCV-3® Standard 1,200 mg Standardized Flavanols Standardized cacao flavanol complex Standardized to spec 1,200 mg cacao flavanols / scoop Vegan · Non-GMO Subscribe & Save 20%
Begin the ritual

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