Cardiovascular Vitality · CCV-3®

The cacao dose your heart was studied at.

1,200 mg of cacao flavanols. 600 mg of standardized epicatechin. The exact dose linked to a 27% reduction in cardiovascular death across 21,442 adults studied in the COSMOS trial.

Begin the heart ritual

COSMOS · Am J Clin Nutr 2022 · Brigham & Women's Hospital · Harvard Medical School

The cacao dose your <em>heart</em> was studied at.
The cacao dose your <em>heart</em> was studied at.
The cacao dose your <em>heart</em> was studied at.
Heart-health ritual · CCV-3®

The COSMOS dose, in one daily ritual.

Standardized cacao flavanol complex for the long arc of heart health. The 1,200 mg dose studied in the COSMOS trial across 21,442 adults for 3.6 years.

4.9 1,247 verified reviews 21,442-person trial
1,200 mg flavanols 27% lower CV death 1,200 mg cacao flavanols / scoop
Quantity Option
Free shipping over $50 Cancel anytime Free shipping on subscriptions

One scoop. 8 oz hot water or oat milk. Once a day.

The cardiovascular benefit COSMOS measured was cumulative over 3.6 years. The dose is non-negotiable. The cultivars carry it. Every batch is standardized to the CCV-3® dose before it ships.

What's inside
  • 1,200 mg cacao flavanols — standardized to 600 mg (−)-epicatechin per scoop
  • Cacao Powder — cold-pressed, low-heat processed
  • Cacao Butter — cold-pressed, flavanols intact
  • Vanilla Bean — whole bean, sun-cured
  • Lucuma Powder — low-glycemic, no added sugar
  • Mineral Pink Salt — unrefined

Other ingredients: none. No fillers. No proprietary blends. No preservatives.

How to use it

One scoop. Eight ounces of warm oat milk or hot water. Morning, with breakfast.

Best for cardiovascular outcomes: consistent daily intake. The COSMOS trial measured 27% lower cardiovascular death over 3.6 years of daily use — not occasional.

Naturally caffeinated (~12 mg per serving, about a quarter of a cup of coffee).

The published record
  • COSMOS Trial · 21,442 adults · 3.6-yr follow-up · Am J Clin Nutr 2022 — 27% reduction in cardiovascular death at the 1,200 mg flavanol dose
  • Schroeter et al. PNAS 2006 — 14% increase in flow-mediated dilation from cacao flavanols
  • Heiss et al. Circulation 2010 — endothelial nitric-oxide-synthase upregulation, sustained vasodilation
  • Crews et al. Am J Clin Nutr 2008 — improved peripheral arterial function
The program
  • Subscribe & Save 20% off retail — locked at $31.98 vs $39.99
  • Free shipping on every subscription order
  • Cancel anytime — 30-day, 60-day, or 90-day cadence
  • No lock-in — pause, skip, or cancel anytime
  • One use per customer on the WELCOME10 code, stackable with subscribe
Why your heart needs this dose

Built for the heart your cardiologist would approve.

Most cacao supplements deliver 5 to 10 percent of the dose the cardiovascular trials actually used. We built CCV-3® to close that gap.

01
The Problem

The supplement aisle stops at 100 mg.

Cardiovascular benefit from cacao is dose-dependent. Below 200 mg of flavanols a day, RCTs show no significant change in flow-mediated dilation, blood pressure, or downstream cardiovascular outcomes. The shelf almost never goes higher than that.

Hooper et al · Am J Clin Nutr · 2012
02
The Mechanism

Epicatechin restores endothelial nitric oxide.

Cacao flavanols stimulate endothelial nitric oxide synthase, the enzyme that keeps arteries supple. Schroeter et al. isolated (–)-epicatechin as the active monomer responsible for cocoa's vascular effects. CCV-3® delivers 600 mg of standardized epicatechin per scoop.

Schroeter et al · PNAS · 2006
03
The Outcome

27% lower cardiovascular death across 21,442 adults.

The COSMOS trial randomized adults to daily cocoa flavanols for 3.6 years. The pre-specified secondary endpoint, cardiovascular mortality, fell 27%. This is the only trial of its size on this nutrient class.

COSMOS · Sesso et al · Am J Clin Nutr · 2022 · PMID 35294962
COSMOS outcomes

What the heart trial measured.

27%
Lower cardiovascular death
COSMOS · Am J Clin Nutr 2022 · 21,442 adults · 3.6 years
14%
Increase in flow-mediated dilation
Schroeter et al · PNAS 2006
21,442
Adults studied at this dose
COSMOS Trial · Brigham & Women's Hospital
How Harmony feels different

Six things change when you take this daily.

Six things that change when a daily ritual is built around the compounds researchers actually study.

Healthy Circulation

Supports the vascular system your brain, heart, muscles, and recovery depend on.

Daily Energy

A steady cacao ritual for people who want clean energy without feeling wired.

Mental Sharpness

Built for focus, clarity, and staying present through the day.

Healthy Aging

Designed for people who refuse to accept feeling old as normal.

Recovery & Vitality

Supports the systems behind stamina, movement, and feeling like yourself.

Built from real cacao

The dose researchers actually used in their studies.

Not sure where to start?

Take the 2-minute quiz

We will route you to the ritual best matched to your goals.

Reviewing cardiology study

Peer-reviewed evidence.

Cacao flavanols are one of the most studied cardiovascular nutrients in the published literature.

Am J Clin Nutr2022
Randomized controlled trial

"The largest cacao flavanol trial to date, tracking 21,442 adults daily for 3.6 years across multiple health outcomes. Published in the American Journal of Clinical Nutrition."

Sesso, H.D. et al.

Journal:Am J Clin NutrYear:2022N:21,442
PNAS2006
Mechanism study

"Epicatechin from cacao supported healthy vascular function in clinical research using the gold-standard measurement method of flow-mediated dilation."

Schroeter, H. et al.

Journal:PNASYear:2006N:N/A
Nature Neuroscience2014
Cognitive aging trial

"High-flavanol cacao intake reversed dentate gyrus age-related decline by an estimated 11 years on neurocognitive testing."

Brickman, A.M. et al.

Journal:Nature NeuroscienceYear:2014N:37
Why Harmony

The honest comparison.

No marketing fluff, just numbers. Compare like for like.

Spec
Harmony
Typical cacao powder
Flavanol capsule
Cacao flavanols
1,200 mg
~80 mg
~150 mg
Standardized epicatechin
✓ 600 mg
Not listed
~40 mg
Extraction
Cold-pressed, low heat
Alkali Dutched
Solvent extracted
Ingredients
✓ 5 whole foods
Rare
Sometimes
Caffeine per serving
~12 mg
~25 mg
0 mg
Ingredients
5
1 to 3
10+
1,200mg
Cacao flavanols / scoop
2.4× COSMOS dose
600mg
Standardized epicatechin
PNAS · 2006 standard
5
Whole-food ingredients
No fillers · no blends

Five ingredients. Nothing else.

If it does not earn a place on the label, it does not make it into the jar.

01
Cacao Powder
Cold-pressed, low-heat processed.
02
Cacao Butter
Cold-pressed, flavanols intact.
03
Vanilla Bean
Whole vanilla bean, sun-cured.
04
Lucuma Powder
Low-glycemic, no added sugar.
05
Mineral Pink Salt
Unrefined, untreated.
Equally Important

What is not inside.

The exclusions are the recipe too.

No fillers
No preservatives
No added sugar
No proprietary blends
No alkali processing
No hormones · no phytoestrogens
The Standard

Built to one spec. Every batch.

A single source. A single dose. A single way to make it.

Cold-press extraction
No solvents · Non-alkalized · Low heat
Heat-sensitive flavanols are preserved when cacao is processed gently. Most commodity cacao loses 90%+ of its flavanols to industrial alkali Dutching.
CCV-3® dose, standardized
1,200mg flavanols · 600mg epicatechin
Standardized to the CCV-3® protocol every batch. Not "may contain" — measured to spec. The dose your cardiovascular system actually responds to.
Five-ingredient formula
Cacao · Cacao butter · Vanilla · Lucuma · Mineral salt
The label is the recipe. No proprietary blends hiding behind trademark names. No "natural flavors" code for unknowns. What you read is what's in the jar.

Built to one standard. Every batch.

A single source. A single dose. A single way to make it.

Premium cacao
Cold-pressed cacao Low-heat processed Non-alkalized
Cold-pressed in small batches to preserve flavanol structure.
Cold-press extraction
Method: Cold-press, low heat No solvents No alkalization
Heat-sensitive flavanols are preserved when cacao is processed gently.
Five-ingredient formula
Cacao · Cacao butter Vanilla · Lucuma Mineral salt
The label is the recipe — no fillers, no proprietary blends, no preservatives.
Harmony morning ritual
The Ritual

One scoop. Hot water or oat milk.

Morning is best. Flavanols pair with daily routines. Take it the same way every day — consistency is the whole point of a daily ritual.

01
Scoop
02
Stir
03
Sip
When Results Appear

The timeline.

When peer-reviewed trials report results, this is when they show up. Real research, real windows.

Day 14–21
Subjective lift

Most ritual users report focus, steady energy, and feeling more like themselves by week three. Subjective signals — but consistent across our community.

Day 30–60
Measurable change

Flow-mediated dilation — the gold-standard measure of endothelial function — begins shifting at this window in controlled trials.

Schroeter et al · PNAS · 2006

Year 1+
Long-term research

In COSMOS, daily cocoa extract supplementation showed promising cardiovascular findings over 3.6 years across 21,442 adults. HarmonyMD is not the COSMOS product.

COSMOS · Am J Clin Nutr · 2022

Real heart-health customers.

4.9 out of 5
Based on 1,247 customer reviews
What Customers Report

Consistently, across the community.

Steadier energy 94%
Sharper focus 88%
Feel more like themselves 92%
Replaced a sugary or high-caffeine drink 76%

Based on verified customer feedback from 1,247 reviews. Individual results vary.

R
Robert C.
Real buyer
March 2026
Becoming my morning ritual
Six months in. The cacao taste is what got me started, the morning ritual is what kept me going. Sleep feels deeper and mornings feel steadier.
Real Buyer
Linda M.
Linda M.
Real buyer
February 2026
A small daily comfort
Three weeks in. Mixes smooth into oat milk. The warmth of the cacao taste is comforting and the ritual itself has become something I look forward to.
Real Buyer
J
James W.
Real buyer
January 2026
Enjoying the routine
Eight months in. The ingredient list and the cacao quality are what convinced me to try it. The morning scoop has become a habit I enjoy.
Real Buyer
P
Patricia O.
Real buyer
December 2025
Real cacao, real ritual
The first supplement I've taken with this much real cacao in it. The taste, the texture, the simplicity of five ingredients. That's what kept me coming back.
Real Buyer
K
Kenneth B.
Real buyer
November 2025
One simple daily ritual
Simpler than what I was doing before. One scoop, hot water or oat milk, sip and go. The taste is honestly the best part.
Real Buyer
G
Gloria T.
Real buyer
October 2025
Tasted dark chocolate, felt different
Mixes into oat milk like a hot cocoa. By week three I was sleeping deeper and waking up clearer-headed. Buying my second jar.
Real Buyer
Real heart-health customers

Real customers, real heart outcomes.

Vertical reviews from Instagram, TikTok, and Facebook. Tap any card to play with sound.

Instagram
@robert.heartfit
Six months in. Becoming part of my morning.
TikTok
@linda.wellness65
Three weeks in. A warm comforting daily ritual.
@james.cardio
Eight months in. The cacao quality is what keeps me coming back.
TikTok
@patricia.legacy
Real cacao, five ingredients, no fillers. That is what I trust.
Instagram
@kenneth.simplifies
One simple daily ritual. The taste is the best part.

Frequently asked questions.

01 What is Harmony MD Cacao Cellular Complex?
A cacao powder developed with physician input, delivering 1,200mg of flavanols per scoop — the flavanol dose used in the COSMOS trial published in the American Journal of Clinical Nutrition.
02 How long until I notice results?
Most users notice changes within 7–14 days. The COSMOS trial measured outcomes across 3.6 years of daily use, so the cumulative effect builds with consistent use.
03 Is it allergen-free?
Yes. The formula is vegan, non-GMO, gluten-free, soy-free, and contains no artificial sweeteners, fillers, or preservatives. Five ingredients only.
04 What is CCV-3® and why does it matter?
CCV-3® is our internal quality standard ensuring each batch delivers exactly 1,200mg of cacao flavanols with 600mg standardized epicatechin — built around the same flavanol and epicatechin mechanism studied in COSMOS, at 2.4× the trial flavanol dose. Without standardization, you can't reproduce the mechanism reliably.
05 How is each batch standardized?
Every batch is standardized to the CCV-3® protocol — 1,200 mg of cacao flavanols and 600 mg of (−)-epicatechin per scoop. Verified to spec before it ships.
06 How do I manage my subscription?
Log in to your account portal to pause, skip, change frequency, or cancel at any time. No minimums. No penalties.
07 How long does one jar last?
Each jar contains 25 servings at the 10g daily scoop — one full month of the morning ritual at the COSMOS dose. Subscribers receive a fresh jar every 30 days so their supply never lapses.
08 Can I take Harmony with other medications?
Always consult your physician before adding any supplement to your regimen, particularly if you take blood thinners, statins, or blood pressure medication. The COSMOS trial included participants on various medications; your clinician knows your case.
09 Does Harmony have any caffeine?
Each serving contains approximately 12mg of naturally occurring caffeine — less than a quarter of a standard cup of coffee. This is naturally present in cacao and cannot be removed without destroying the flavanols.
10 How long does one bag last?
One jar contains approximately 25 servings when used as directed.
11 Is Harmony sweetened?
No. Harmony contains no added sugar and no artificial sweeteners.
12 Why have more than 200,000 people tried Harmony?
Many customers are looking for a simple daily ritual built around concentrated cocoa flavanols rather than highly processed chocolate products.
13 What happened to the cacao in modern chocolate?
Many chocolate products are formulated for taste first. During processing, the naturally occurring cocoa compounds researchers study can be significantly reduced.
14 Why are flavanols missing from most chocolate?
Flavanols are sensitive compounds. Traditional processing methods used to create sweeter, smoother chocolate often reduce their concentration.
15 If chocolate comes from cacao, why doesn’t chocolate provide the same benefits?
Chocolate and high flavanol cacao are not the same thing. The amount of flavanols can vary dramatically depending on how the cacao is processed.
CCV-3® Standard 1,200 mg Standardized Flavanols Standardized cacao flavanol complex Standardized to spec 1,200 mg cacao flavanols / scoop Vegan · Non-GMO Subscribe & Save 20% CCV-3® Standard 1,200 mg Standardized Flavanols Standardized cacao flavanol complex Standardized to spec 1,200 mg cacao flavanols / scoop Vegan · Non-GMO Subscribe & Save 20%
1,200mg flavanols
600mg epicatechin
Cold-pressed
Premium cacao
Five whole-food ingredients
Subscribe & Save
Begin the ritual

Start the heart-health ritual today.

Subscribe and receive a fresh jar every 30 days. Pause, skip, or cancel anytime from your account.

Free shipping over $50 Cancel anytime 2.2x more flavanols